I had a AMD 7750 card and a AMD FX8350 (8 Cores) ,16GB and Dell UltraSharp™ U2312HM, and I've had GPU acceleration enabled since it was offered, yes, no noticeable improvement by then BUT.... a few weeks ago since an update Lightroom started to crash frequently. I googled a bit and I found the suggestion about disabling GPU acceleration, I did it and...voila... no more crashes, but now the performance of the Develop module has been degraded, it takes more time to load a picture and when you move the slices is a bit slower to see the effects.
It might have been a bad graphics driver, and updating your driver would fix the problem while maintaining the speed improvement from the GPU. Give it a try.